Evolution of selective COX-2 inhibitor from Alangium salvifolium: an in silico approach

Equilibrium Sorption Studies of Malachite Green from Aqueous Solution using Alangium salvifolium Tree Bark

Treatment of dyes from wastewater is obligatory in order to avoid water pollution. Batch adsoprtion studies were carried out to evaluate the potentiality of ba-gases. Various parameters such as initial dye concentration, pH as well as temperature of the system were studied. The adsorption was found to fallow first order kinetics and intraparticle difussion is the date controlling step. The adso...

synthesis of 3-(2-(benzyloxy)phenyl)-5-(methylsulfonyl)-4h-1,2,4-triazole as selective cox-2 inhibitor

Selective COX-2 inhibitor reduces bone healing in bone defects.

Anti-inflammatory agents have been reported to regulate bone healing. The aim of this study was to investigate the effect of a selective cyclooxygenase-2 inhibitor (meloxicam) on bone healing in calvarial defects in rats. Thirty-six adult male Wistar rats were included. After anesthesia, a linear incision was made through the skin of the scalp, a full-thickness flap was reflected and a 4 mm rou...

Growth stimulation of COX-2-negative pancreatic cancer by a selective COX-2 inhibitor.

Cyclooxygenase 2 (COX-2) inhibitors are promising antiangiogenic agents in several preclinical models. The aim of the present study was to evaluate the effect of selective COX-2 inhibitors on vascular endothelial growth factor (VEGF) production in vitro and angiogenesis and growth of pancreatic cancer in vivo, focusing on putative differences between COX-2-negative and COX-2-positive tumors. VE...

Selective COX-2 inhibitor celecoxib prevents experimental autoimmune encephalomyelitis through COX-2-independent pathway.

Cyclooxygenase (COX) is a key enzyme of arachidonic acid metabolism and exists as two distinct isoforms. COX-1 is constitutively expressed in most tissues, whereas COX-2 is inducibly expressed at the site of inflammation. Selective inhibitors of COX-2 have been developed and have been used as anti-inflammatory agents. Here, we show that a new-generation COX-2 inhibitor, celecoxib, inhibited exp...